Carotid body peripheral chemoreceptors are proposed as metabolic sensors that respond to lactate during physical exertion to trigger autonomic and ventilatory responses.
) ventilatory threshold two, correlated with a tremendous increase in breathing and metabolic responses to exercise. Notably, it has been shown that the ventilatory response to exercise increases concomitantly with the release and accumulation of metabolites (i.e., lactate released from skeletal muscle). The principal peripheral chemoreceptors are the carotid bodies (CBs), allocated into the carotid bifurcation and demonstrated to respond to several stimuli, triggering autonomic and ventilatory responses. Indeed, in past and recent years, it has been shown that CB could respond to lactate in in vitro and in vivo preparations, eliciting an increase in CB activity and ventilation. However, not all evidence indicates that peripheral chemoreceptors respond to lactate. Thus, considering that CB chemoreceptors' role in lactate-dependent breathing response is not completely clear and their potential preponderance as metabolic sensors during exercise has not been thoroughly explored, the present review was focused on the possible role of CB chemoreceptors as metabolic sensors during physical exertion in a physiological context, proposing it as a new actor in exercise physiology.
David C. Andrade (Wed,) conducted a review in Physical exertion. Carotid body chemoreceptors was evaluated. Carotid body peripheral chemoreceptors are proposed as metabolic sensors that respond to lactate during physical exertion to trigger autonomic and ventilatory responses.