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Introduction: Mycophenolate mofetil (MMF) is an immunosuppressive drug administered in the management of both autoimmune diseases and organ transplantation. The main aims of the study were: (a) to obtain information regarding the safety of using MMF in respect of its effect on normal T and B cells in lymphoid tissues; (b) to investigate whether the generation of inducible Foxp3-expressing regulatory T cells (Treg) might constitute additional mechanisms underlying the immunosuppressive properties of MMF. Methods: studies). Results: T cells resulting in the shift of the Treg cell/activated Teff cell balance toward an increased proportion of Treg cells. Conclusion: Treg cells.
Krawczyk et al. (Tue,) studied this question.