Graph neural networks in histopathology: Emerging trends and future directions

Histopathological analysis of whole slide images (WSIs) has seen a surge in the utilization of deep learning methods, particularly Convolutional Neural Networks (CNNs). However, CNNs often fail to capture the intricate spatial dependencies inherent in WSIs. Graph Neural Networks (GNNs) present a promising alternative, adept at directly modeling pairwise interactions and effectively discerning the topological tissue and cellular structures within WSIs. Recognizing the pressing need for deep learning techniques that harness the topological structure of WSIs, the application of GNNs in histopathology has experienced rapid growth. In this comprehensive review, we survey GNNs in histopathology, discuss their applications, and explore emerging trends that pave the way for future advancements in the field. We begin by elucidating the fundamentals of GNNs and their potential applications in histopathology. Leveraging quantitative literature analysis, we explore four emerging trends: Hierarchical GNNs , Adaptive Graph Structure Learning , Multimodal GNNs , and Higher-order GNNs . Through an in-depth exploration of these trends, we offer insights into the evolving landscape of GNNs in histopathological analysis. Based on our findings, we propose future directions to propel the field forward. Our analysis serves to guide researchers and practitioners towards innovative approaches and methodologies, fostering advancements in histopathological analysis through the lens of graph neural networks. • Graph neural networks (GNNs) are an increasingly popular modeling technique in histopathology, offering several advantages over traditional deep learning approaches. • We provide a theoretical and methodological background on the applications of GNNs in histopathology. • Using quantitative literature analysis, we identify four emerging trends which we explore further. • Based on our gained insight, we provide future directions for the field.