Although thyroid volume correlated with superficial femoral artery IMT (R=0.407, p=0.007), multiple linear regression confirmed thyroid status does not significantly affect IMT values.
Cross-Sectional (n=45)
Is there an association between thyroid volume/function and carotid/femoral intima-media thickness in euthyroid patients?
In euthyroid patients, thyroid volume correlates with femoral IMT, but this relationship is not independent of comorbidities like diabetes and hypertension.
Effect estimate: R = 0.407
p-value: p=0.007
Background/Objectives: The interrelationship of thyroid volume and function with features of cardiovascular dysfunction has already been investigated but some aspects remain unclear, especially in terms of subclinical cardiovascular dysfunction in euthyroid patients. Intima-media thickness (IMT) measurement in ultrasound B-mode imaging in different vascular beds (most frequently within the common carotid artery) is one of the most important tools for the detection of subclinical atherosclerosis in both clinical practice and research. This article aimed to present the results of our research on the association between the thyroid evaluation parameters and the IMT measured in both the carotid and femoral arteries in euthyroid patients aged 18 to 65 years taking into account the influence of diabetes, hypertension, and excess body mass. Methods: We performed a retrospective cross-sectional analysis of data from patients with no thyroid disease who during planned hospitalization underwent thyroid ultrasound, determination of biochemical parameters of thyroid function, and Doppler ultrasound of carotid, vertebral, and lower extremities arteries with IMT measurement. Data from 45 people (females: 57.8%) were analyzed. Results: No significant correlations were found between biochemical parameters of thyroid function and IMT parameters. Thyroid volume was found to be significantly correlated with all parameters of the IMT within the superficial femoral artery (R = 0.407, p = 0.007 for the mean IMT calculated from the left side and the right side) and with minimal IMT within the common femoral artery taken from the left side and the right side (R = 0.342, p = 0.025). Selected IMT parameters were shown to be significantly higher in patients with arterial hypertension, diabetes, obesity, or metabolic syndrome in comparison to patients without the mentioned comorbidities. Using multiple linear regression, it was confirmed that parameters related to thyroid status do not significantly affect the IMT value. A significant effect of diabetes and, to a lesser extent, hypertension on the IMT value was confirmed, especially in the femoral arteries. Conclusions: In the population of euthyroid patients, thyroid volume correlates significantly with some parameters of femoral IMT. No significant correlations were found between thyroid biochemical parameters and IMT in both carotid and femoral arteries. A significant influence of diabetes and hypertension on the IMT value was confirmed, especially in the femoral arteries.
Jakubiak et al. (Sat,) conducted a cross-sectional in Euthyroid (n=45). Thyroid volume and function was evaluated on Intima-media thickness (IMT) in carotid and femoral arteries (R = 0.407, p=0.007). Although thyroid volume correlated with superficial femoral artery IMT (R=0.407, p=0.007), multiple linear regression confirmed thyroid status does not significantly affect IMT values.
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