Key points are not available for this paper at this time.
Gonorrhoea is currently one of the most important sexually transmitted infections (STIs) due to the increasing spread of multidrug-resistant strains of N. gonorrhoeae . The aim of this study was to analyse the association between resistance or decreased susceptibility to antibiotics in N. gonorrhoeae and the presence of mutations in the pen A, mtr R, gyr A and par C genes, and the presence of tetM gene. We conducted a systematic review according to the PRISMA guidelines. We selected 19 studies for the pen A gene, 23 for gyr A and par C, 18 for mtr R and 12 for tet M using the Science Direct and PubMed databases. Meta-analyses of isolates resistant to penicillin, cefixime and ceftriaxone showed that more than 50% of isolates had mutations in the pen A and mtr R genes. More than 50% of azithromycin-resistant isolates had mutations in the mtr R gene, while more than 50% of ciprofloxacin-resistant and intermediate-resistant isolates had mutations in gyr A. Less than 50% of the isolates with intermediate resistance to ciprofloxacin had mutations in par C. The plasmid containing the tet M gene was found in more than 50% of tetracycline-resistant isolates. Infection surveillance and genetic studies are important for controlling the spread of the disease, which can improve the quality of life of infected people and reduce the financial burden on public health systems.
Mendes et al. (Wed,) studied this question.