Mutant-type ALDH2 was associated with a significantly lower rate of change in coronary reference diameter after intracoronary nitroglycerin compared to wild-type (9.6% vs 15.8%, P<0.001).
Observational (n=427)
Does ALDH2 gene polymorphism affect the vasodilative effect of intracoronary nitroglycerin in patients with suspected angina pectoris?
ALDH2 gene polymorphism (Glu504Lys) significantly attenuates the vasodilative response of coronary arteries to intracoronary nitroglycerin.
Tasa de eventos absoluta: 9.6% vs 15.8%
valor p: p=<0.001
ABSTRACT: Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that facilitates the biologic metabolism of nitroglycerin. However, no study investigated the association between ALDH2 gene polymorphism and the vasodilation of coronary arteries after intracoronary administration of nitroglycerin. In this study, we enrolled 427 patients with suspected angina pectoris. ALDH2 genotyping was performed and all patients were given 200 µg nitroglycerin in the right coronary artery during the coronary angiography. The invasive hemodynamic parameters including systolic blood pressure (SBP), diastolic blood pressure, and heart rate were monitored. The reference diameter and stenosis diameter of the right coronary artery were measured with the Stenosis Analysis 1.6 software. Both wild-type and mutant-type groups exhibited significant decreases in SBP, diastolic blood pressure values, and increases in heart rate value after administration of nitroglycerin ( P 0.05). In conclusion, ALDH2 gene polymorphism (Glu504Lys) is associated with changes in invasive hemodynamic parameters and coronary artery diameter after intracoronary injection of nitroglycerin.
Zhang et al. (Mon,) conducted a observational in suspected angina pectoris (n=427). ALDH2 gene polymorphism (mutant-type) vs. ALDH2 wild-type was evaluated on rate of change in reference diameter (%) (p=<0.001). Mutant-type ALDH2 was associated with a significantly lower rate of change in coronary reference diameter after intracoronary nitroglycerin compared to wild-type (9.6% vs 15.8%, P<0.001).