A systematic review of 40 studies found significant variation in severe maternal morbidity definitions, with median incidences of 11.4/1000 (administrative data) and 6.7/1000 (medical records).
Systematic Review (n=40)
There is significant variation in the composite definitions of severe maternal morbidity used in high-income settings, highlighting the need for harmonization to facilitate comparisons between maternity systems.
Background: Severe maternal morbidity (SMM) is an important indicator for the improvement of maternity care. Measurement of SMM varies, limiting global comparisons. To promote concordance we studied how SMM has been defined in epidemiological practice. Methods: Comprehensive composite definitions of SMM in pregnancy or up to 6 weeks postnatal that captured both obstetric and non-obstetric processes in high-income settings were identified through a prospectively registered (PROSPERO CRD42023421377) systematic search of PubMed, Embase, and Google Scholar 01/01/1993-31/08/2024. Clinical concepts, diagnostic and procedural codes captured by definitions of SMM were compared and the variation between definitions was described. Findings: The initial search identified 7852 records and 40 studies were included: 28 studies that reported 32 definitions of SMM for use with administrative data, with median incidence of 11.4/1000, and 13 studies that reported 13 definitions for use with the primary medical record, with median SMM incidence of 6.7/1000. The majority of definitions included cardiac, respiratory, and renal dysfunction or failure; haemorrhagic, thrombotic or infective morbidity; and critical interventions. Up to 75% of cases of SMM under some definitions involved transfusion. The main source of variation between definitions was the selection and definition of common obstetric diagnoses. Variation in the sources of additional routine data required to construct a definition also limited comparability. Interpretation: Despite common approaches to defining SMM, there are opportunities to improve comparability. No two definitions for use with administrative data in different settings involved a similar incidence and set of components and involved a similar distribution of components among cases. Harmonization of the purpose, constituent codes, and sources of data would facilitate comparisons between maternity systems. Funding: This work was supported by the Medical Research Council MR/X006115/1 as well as the National Institute for Health Research NIHR204430.
Henderson et al. (Thu,) conducted a systematic review in Severe maternal morbidity (n=40). Composite definitions of severe maternal morbidity was evaluated on Variation between definitions of severe maternal morbidity. A systematic review of 40 studies found significant variation in severe maternal morbidity definitions, with median incidences of 11.4/1000 (administrative data) and 6.7/1000 (medical records).