Diastolic dysfunction in HIV-infected patients increased the risk of death within 2 years by 1.46 times.
Cross-Sectional (n=240)
Does diastolic dysfunction increase the risk of death and cardiovascular disease progression in HIV-infected patients?
Diastolic dysfunction is common in HIV-infected patients and is associated with a 1.46-fold increased risk of 2-year mortality and elevated NT-proBNP levels.
Relative Risk: 1.46
Diastolic dysfunction in HIV-infected patients is a common problem, the pathway of which is based on chronic low-intensity inflammation, and whose consequences are associated with progression of chronic heart failure (CHF) and death. The aim of the study was to evaluate clinical, echocardiographic and laboratory data of patients with diastolic left ventricular myocardial dysfunction infected with HIV and to present new prognostic relationships. Within the framework of a one-stage, screening, clinical study in the conditions of a multidisciplinary clinic, 240 patients with HIV infection were examined, and 136 of them showed signs of diastolic dysfunction. The development of diastolic dysfunction in HIV-infected patients is a factor provoking the development and progression of CVD, ventricular rhythm disturbances, ischemic heart disease, and anemia. Diastolic dysfunction in HIV-infected patients increases the risks of death within 2 years by 1.46 times. Increase of NT-proBNP concentration in plasma of HIV-infected patients ≥ 185.7 pg/mL is associated with the development of diastolic dysfunction in them.
O. G. Goryacheva (2025) conducted a cross-sectional in HIV infection (n=240). Diastolic dysfunction vs. No diastolic dysfunction was evaluated on Death within 2 years (1.46 times increased risk). Diastolic dysfunction in HIV-infected patients increased the risk of death within 2 years by 1.46 times.