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[68Ga]Ga-FAPI-04 is a promising PET imaging agent for assessing solitary fibrous tumors, which exhibit high FAP expression that could serve as a novel therapeutic target. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 6, 2025Open Access

Comparison of 68GaGa-Fibroblast Activation Protein Inhibitor–04 and 18FFDG PET Imaging for Solitary Fibrous Tumor and Preliminary Application of FAP-Targeted Radiopharmaceutical Therapy

RWRongxi WangChinese Academy of Medical Sciences & Peking Union Medical College JWJiarou WangChinese Academy of Medical Sciences & Peking Union Medical College JXJialin XiangChinese Academy of Medical Sciences & Peking Union Medical College

Key Result

[68Ga]Ga-FAPI-04 is a promising PET imaging agent for assessing solitary fibrous tumors, which exhibit high FAP expression that may serve as a potential therapeutic target.

Structured PICO

Does [68Ga]Ga-FAPI-04 PET imaging improve the assessment of solitary fibrous tumors compared to [18F]FDG PET imaging?

Population

Patients with Solitary Fibrous Tumor (SFT)

Intervention

[68Ga]Ga-Fibroblast Activation Protein Inhibitor-04 PET imaging

Comparator

[18F]FDG PET imaging

Outcome

Assessment of SFTssurrogate

[68Ga]Ga-FAPI-04 is a promising PET imaging agent and potential therapeutic target for solitary fibrous tumors.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Ga]Ga-FAPI-04 may be a promising PET agent for the assessment of SFTs. Given the lack of effective treatments for advanced SFTs, high FAP expression in this type of tumor is expected to become a potential treatment target.

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