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• In the MM patient population, myosteatosis characterized by FIR was not significantly associated with survival prognosis. • MM patients with severe fat infiltration had a significantly increased risk of fractures. Myosteatosis appears to be one of the causes of persistent lower back pain and functional limitations in patients with mild MM. • Subgroup analysis suggests that the predictive efficacy of FIR for fractures is higher in the general population; however, this efficacy is weakened in patients with BMI ≥ 25 kg/m 2 or RBC count >3. 68 × 10¹2/L. • Age, BMI, gender, and RBC levels are independent factors influencing myosteatosis in MM patients. The nomogram constructed based on these four predictive indicators was well-validated. • The clinical intervention principles for MM patients with high degrees of myosteatosis were summarized. This study aims to explore the prognostic value of myosteatosis in multiple myeloma (MM) and to analyze the factors influencing myosteatosis. A retrospective analysis was conducted on 182 patients treated for MM at our institution from 2009 to 2020 who underwent MRI examinations. The fatty infiltration rate (FIR) of the erector spinae and multifidus muscles at the L3 level was measured to assess the degree of myosteatosis. Patients were grouped based on fracture presence and median FIR, and group differences were compared, with P 0. 05). In subgroups with BMI ≥ 25 kg/m 2 or RBC count > 3. 68 × 10¹2/L, FIR lost its predictive significance for fractures. The FIR nomogram model had a C-index of 0. 777, and the calibration curve, decision curve analysis, and clinical impact curve all validated its effectiveness. Myosteatosis characterized by FIR is not a reliable predictor of survival in MM patients but is effective in predicting fractures and is closely related to back pain and functional impairment. FIR is significantly associated with age, sex, RBC count, and BMI
Liu et al. (Tue,) studied this question.