March 18, 2025Open Access

Single-cell RNA sequencing and spatial transcriptomics reveal the heterogeneity and intercellular communication of cancer-associated fibroblasts in gastric cancer

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Abstract

Our study provided a comprehensive characterization of CAF heterogeneity in gastric cancer and revealed the intricate intercellular networks within the TME. The identified CAF subpopulations and their interactions with malignant cells could serve as potential therapeutic targets.

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Zhang et al. (Tue,) studied this question.

synapsesocial.com/papers/69df502f6324afb55d59270d https://doi.org/https://doi.org/10.1186/s12967-025-06376-8

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