Baseline peak atrial longitudinal strain was significantly lower in patients who developed future atrial fibrillation compared to those who remained in sinus rhythm (WMD -5.55%; 95% CI -7.06 to -4.03%).
Meta-Analysis (n=1,230)
Do decreased peak atrial longitudinal strain and left atrial contraction strain rate values predict future atrial fibrillation in patients in sinus rhythm at baseline?
Baseline peak atrial longitudinal strain and contraction strain rate are significantly lower in patients who subsequently develop atrial fibrillation, suggesting these echocardiographic parameters could help identify patients needing prolonged rhythm monitoring.
Mean Difference: -5.55 (95% CI -7.06–-4.03)
Despite the broadening spectrum of heart rhythm-monitoring techniques, the most appropriate modality and duration to detect atrial fibrillation (AF) are not consensual. Two-dimensional speckle tracking for left atrial strain analysis seems feasible to detect atrial cardiomyopathy, which represents a substrate for AF. We aimed to perform a systematic review and meta-analysis on peak atrial longitudinal strain (PALS) and contraction strain rate (pLAct) differences as primary outcomes measured in sinus rhythm (SR) between patients with and without future AF during follow-up (FU). Random-effect model was used. For continuous outcomes, we calculated weighted mean differences (WMD) to compare the two groups We identified eight eligible articles consisting of 1230 patients. Six articles were eligible for quantitative PALS analysis, while three were eligible regarding pLAct. The baseline parameters of the future AF and SR patients were comparable in most of the papers. The PALS value in patients developing future AF was significantly lower compared to patients with no AF (WMD: -5.55% 95% CI -7.06 to -4.03%). Pooled WMD of pLAct between the groups was -0.44 1/s, 95% CI: -0.56 to -0.33 1/s. Baseline PALS and pLAct values of future AF patients were significantly lower than those who remained in SR during FU. PALS and pLAct seem to be sensitive parameters which can be implemented in a predictive model for AF enabling us to find patients who need prolonged heart rhythm-monitoringand it can be also a guidance for oral anticoagulation indication setting.
Mészáros et al. (Thu,) conducted a meta-analysis in Sinus rhythm (n=1,230). Future atrial fibrillation vs. No future atrial fibrillation (remained in sinus rhythm) was evaluated on Peak atrial longitudinal strain (PALS) (WMD -5.55%, 95% CI -7.06 to -4.03). Baseline peak atrial longitudinal strain was significantly lower in patients who developed future atrial fibrillation compared to those who remained in sinus rhythm (WMD -5.55%; 95% CI -7.06 to -4.03%).
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