Why the study?
Little is known about the predictive power of the TyG index, SHR, and their combination on the incidence and mortality risks of new-onset atrial fibrillation in patients with sepsis.
Do high TyG index and SHR increase the risk of new-onset atrial fibrillation and mortality in patients with sepsis?
Population
4276 patients with sepsis from the MIMIC-IV database
Comparison
Highest vs lowest groups of TyG index, SHR, and their combination
Design
Retrospective cohort study
Follow-up
360-day
Key result
In septic patients who developed in-hospital new-onset atrial fibrillation, concurrent high levels of the triglyceride-glucose index and stress hyperglycemia ratio significantly increased the risk of 360-day mortality (HR 1.72).
Authors
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May aid NOAF risk stratification in sepsis; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=4,276)
No
Do high TyG index and SHR increase the risk of new-onset atrial fibrillation and mortality in patients with sepsis?
Hazard Ratio: 1.72 (95% CI 1.08–2.72)
p-value: p=0.021
Zuo et al. (2025) conducted a cohort in Sepsis (n=4,276). High triglyceride-glucose (TyG) index and high stress hyperglycemia ratio (SHR) vs. Low TyG index and low SHR was evaluated on 360-day mortality in septic patients with in-hospital new-onset atrial fibrillation (HR 1.72, 95% CI 1.08-2.72, p=0.021). In septic patients who developed in-hospital new-onset atrial fibrillation, concurrent high levels of the triglyceride-glucose index and stress hyperglycemia ratio significantly increased the risk of 360-day mortality (HR 1.72).