Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds

broad-spectrum antioxidant activity and macrophage phenotype regulation, restoring tissue redox and immune homeostasis. Furthermore, the hydrogels can stabilize and release the engineered exosomes. By integration of generation and release of VEGF by plasmids-loaded macrophage Exos, VEGF secretion by M2 macrophages, and enhanced binding of VEGF to VEGF receptor 2 by high affinity of sulfated chitosan, the intrinsic immunomodulatory hydrogels effectively promote the angiogenesis and accelerate the diabetic wound healing process.