Initiating antihypertensive monotherapy within the first month after diagnosis leads to better blood pressure control at 6 to 30 months compared to later initiation (P<0.001).
Cohort (n=15,422)
Yes
Does initiating antihypertensive monotherapy within the first month of diagnosis improve blood pressure control in adults with newly diagnosed hypertension?
Initiating antihypertensive monotherapy within the first month of diagnosis significantly improves blood pressure control between 6 and 30 months compared to delayed treatment.
p-value: p=<0.001
BACKGROUND: Adults with hypertension have fewer cardiovascular events if controlled within the first 6 months of diagnosis, during which time they are excluded from many hypertension control metrics. We compared blood pressure (BP, mm Hg) control rates from 6 to 42 months in adults with hypertension who did or did not have antihypertensive treatment initiated (TI) with monotherapy during the first month after diagnosis, irrespective of subsequent changes in antihypertensive pharmacotherapy. METHODS: A retrospective cohort of 15 422 patients, mean age 56.0±14.8 years, from 5 health care organizations, was identified with previously undiagnosed and untreated hypertension. BP control (30% of patients.
Barrett et al. (Mon,) conducted a cohort in Hypertension (n=15,422). Antihypertensive treatment initiated with monotherapy during the first month after diagnosis vs. No antihypertensive treatment initiated during the first month was evaluated on Blood pressure control (<140/<90 mm Hg) over time (p=<0.001). Initiating antihypertensive monotherapy within the first month after diagnosis leads to better blood pressure control at 6 to 30 months compared to later initiation (P<0.001).