Patients with cardiac pathologies exhibited significantly higher native T1 values at 5T compared to healthy volunteers (1638.7 ms vs 1506.2 ms).
Observational (n=39)
No
Is myocardial T1 mapping and extracellular volume measurement feasible at 5T MRI to establish reference values?
Myocardial T1 mapping at 5T is feasible and provides distinct reference values for healthy myocardium compared to pathological states.
Absolute Event Rate: 1638.7% vs 1506.2%
p-value: p=<0.001
BACKGROUND: T1 mapping is a robust and highly reproducible technique for quantitative assessment of cardiomyopathy. The aim of this study is to investigate the feasibility of 5T myocardial T1 mapping and to establish preliminary reference values for myocardial T1 at 5T. METHODS: Twenty-eight healthy volunteers (median age, 42 interquartile range (IQR): 29-54 years; 14 male) and 11 patients (median age, 44 IQR: 34-51 years; 7 male) underwent cardiovascular magnetic resonance at 5T. T1 mapping was acquired using a motion-corrected modified Look-Locker inversion recovery sequence 5(3)3 scheme for pre-contrast, (4(1)3(1)2) scheme for post-contrast in three short-axis planes (base, middle, and apex). T1 values were quantified per segment, per slice, and globally. RESULTS: Healthy volunteers had a mean global native T1 value of 1506.2 ± 41.7 ms, with T1 values decreasing progressively from the base to the apex slice (P = 0.08). Significantly higher T1 values were revealed in the septum compared to the non-septal myocardium (1540.1 ± 69.3 vs 1477.6 ± 93.7, P 0.05). Within the spectrum of cardiac pathologies analyzed in this study, patients exhibited higher native T1 values (1638.7 ± 108.6 ms vs 1506.2 ± 41.7 ms, P < 0.001) and higher extracellular volume fraction (37.5% ± 5.5% vs 29.5% ± 2.1%, P = 0.074) compared to healthy volunteers, late gadolinium enhancement (LGE)-positive segments exhibited significantly higher T1 values than LGE-negative segments (1685.2 ± 144.1 vs 1582.6 ± 88.7, P < 0.001). There was excellent intra-scanner test-retest, intra-observer, and inter-observer reproducibility for measurement of native T1. CONCLUSION: The present study demonstrated the feasibility of T1 mapping quantification at 5T and presented mean native T1 values in healthy human myocardium at this field strength, which can be used as reference values specific for this magnetic resonance setting.
Guo et al. (Wed,) conducted a observational in Cardiac pathologies (n=39). 5T cardiovascular magnetic resonance T1 mapping vs. Healthy volunteers was evaluated on Native T1 values (p=<0.001). Patients with cardiac pathologies exhibited significantly higher native T1 values at 5T compared to healthy volunteers (1638.7 ms vs 1506.2 ms).