Advances in flavonoid bioactivity in chronic diseases and bioavailability: transporters and enzymes

Flavonoids, abundant in the human diet, have been extensively studied for their therapeutic bioactivities. Recent research has made significantly advances in our understanding of the biological activities of flavonoids, demonstrating their therapeutic effects for various chronic diseases. However, the generally low bioavailability of flavonoids limits their effectiveness. Therefore, it is essential to explore the pharmacokinetics of flavonoids, paying particular attention to the roles of transporters and metabolizing enzymes. This paper reviews recent studies on the bioactivity of flavonoids, highlighting the importance of transporters and metabolic enzymes in their pharmacokinetics.