MASLD was detected in 80.4% of patients with newly diagnosed type 2 diabetes mellitus, with ALT and BMI identified as independent predictors of the disease.
Observational (n=128)
What is the prevalence and what are the risk factors for MASLD in patients with newly diagnosed type 2 diabetes mellitus?
There is a high prevalence (80.4%) of MASLD in newly diagnosed T2DM patients, highlighting the need for early screening and detection.
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) represents a growing concern in the context of metabolic disorders, particularly among individuals diagnosed with type 2 diabetes mellitus (T2DM). This study aimed to investigate the prevalence of MASLD among newly diagnosed T2DM patients and identify the risk factors for MASLD in this population. Methods: This prospective study included 128 patients with newly diagnosed T2DM between January 2022 and June 2023. Demographic, clinical, anthropometric (BMI, waist circumference), and laboratory data (glucose, HbA1c, lipid profile, ALT, AST, creatinine, platelet count) were collected. MASLD was diagnosed based on ultrasonographic evidence of hepatic steatosis with at least one cardiometabolic risk factor after excluding other causes. Linear regression models were used to determine independent predictors. Results: MASLD was detected in 80.4% of patients. Compared with the MASLD (−) group, the MASLD (+) group had significantly higher ALT (47.1 ± 23 U/L vs. 24.9 ± 8 U/L, p < 0.001) and non-HDL cholesterol (189 ± 57 mg/dL vs. 167 ± 28 mg/dL, p = 0.047). Spearman correlation showed positive associations of MASLD severity with waist circumference, LDL cholesterol, and platelet count. ALT and BMI were independently associated with MASLD in linear regression analysis. Conclusions: This study underscores the significant prevalence of MASLD in newly diagnosed T2DM patients, emphasizing the relevance of early detection in addressing this common comorbidity in the diabetic population.
Polat et al. (Sat,) conducted a observational in Newly diagnosed type 2 diabetes mellitus (n=128). MASLD vs. No MASLD was evaluated on Prevalence of MASLD. MASLD was detected in 80.4% of patients with newly diagnosed type 2 diabetes mellitus, with ALT and BMI identified as independent predictors of the disease.
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