Vascular microphysiological systems based on organ-on-a-chip technologies provide biologically relevant models for investigating vascular biology, disease modeling, and drug screening.
Vascular microphysiological systems provide biologically relevant models for disease modeling and drug development by mimicking physiological environments.
models, specifically vascular microphysiological systems (MPS) based on organ-on-a-chip (OoC) technologies. This review highlights the relevance and potency of vascular MPS, which leverage microfluidic channels and 3D structures to mimic the physiological environment, incorporate diverse cellular and acellular components, and support complex biological processes. Vascular MPS are already enabling deep investigation into vascular responses to physiological cues, interactions with healthy and pathological tissues, and applications in disease modeling and drug development.
Breuil et al. (Wed,) conducted a review in Vascular biology and pathology. Vascular microphysiological systems (MPS) vs. Traditional in vitro and in vivo models was evaluated. Vascular microphysiological systems based on organ-on-a-chip technologies provide biologically relevant models for investigating vascular biology, disease modeling, and drug screening.