Hydraulic forces assist left ventricular filling in aortic stenosis and improve after valve replacement in patients with the lowest hydraulic force and otherwise healthiest left ventricles at baseline

ABSTRACT Background Diastolic dysfunction in the setting of aortic valve replacement (AVR) for aortic stenosis (AS) is incompletely understood. This study aims to to assess the net hydraulic force of left ventricular (LV) filling in participants with severe symptomatic AS undergoing AVR. Methods This single-centre prospective observational cohort study evaluated patients with severe, symptomatic AS undergoing AVR between 2012-2015. Clinical assessment and cardiovascular magnetic resonance (CMR) was completed prior to AVR and 1-year post-operatively. Atrioventricular area difference (AVAD) was used as a surrogate for the hydraulic force of LV filling. AVAD at mid-diastole was measured as the difference between LV short-axis area and left atrial short-axis area. Results In patients with AS (n=110, 54% male, age 71 64–77 years, aortic valve area 0.74±0.25 cm 2 ), AVAD was positive at baseline (2.8±6.5 cm 2 ) consistent with a net hydraulic force assisting LV filling. While AVAD did not change post-operatively on a group level (p=0.70), an improvement in AVAD was associated univariably with increasing baseline LV ejection fraction, and decreasing baseline AVAD, LV volume, mass, myocardial extracellular volume, and infarct size (p<0.05 for all), and multivariably with baseline decreasing AVAD, LV mass, and age (model adjusted R 2 =0.49, p<0.001). Conclusion In severe AS, hydraulic force contributes to LV filling prior to and following AVR. The greatest improvement in hydraulic force following AVR occurred in those with the lowest baseline hydraulic force, but also with lower age and the absence of otherwise deleterious LV myocardial remodelling, thus supporting the benefits of early intervention.