Altered Levels of miRNA-1290 and lncRNA-H19 in Exosomes of Patients Recently Diagnosed With Acute Lymphoblastic Leukemia

BACKGROUND/AIM: -acetyltransferases 1 (NAT1), regulated by microRNA (miRNA) and long noncoding RNA (lncRNA), have been associated with predisposition to ALL. This study analyzed the characteristics of exosomes from patients newly diagnosed with ALL, patients already under ALL treatment, and healthy controls. MATERIALS AND METHODS: from exosomes were determined using a ZetaSizer Nano ZS instrument, flow cytometry and reverse transcription polymerase chain reaction, respectively. RESULTS: compared with controls. CONCLUSION: These findings suggest that exosomes not only reflect the pathophysiology of ALL but may also play a crucial role in its development and progression. Furthermore, exosomes and their non-coding RNA content emerge as potential biomarkers for ALL diagnosis and prognosis, opening avenues for future research to explore their functional role and therapeutic potential.