ABSTRACT Breast cancer currently exhibits the highest incidence rate among gynecological malignancies worldwide. Natural products, which have been extensively utilized in antiviral therapies globally, demonstrate unique therapeutic advantages in breast cancer management through combinatorial applications. This article reviews recent advances in both the therapeutic effectiveness and underlying mechanisms of natural product combination therapy for breast cancer. These combinations simultaneously target multiple oncogenic pathways by inhibiting cellular proliferation and viability, suppressing autophagy and angiogenesis, blocking invasion and metastasis, and inducing cell cycle arrest and apoptosis. Beyond their direct anticancer effects, natural product combinations modulate immune responses and remodel the tumor microenvironment, offering novel therapeutic perspectives. However, rigorously designed clinical trials remain essential to validate the clinical efficacy of natural product‐chemotherapeutic combinations in breast cancer treatment.
Wang et al. (Mon,) studied this question.