Bidirectional Interaction in Cardio-Oncology Toward Novel Therapeutic Strategies for Cardiovascular Diseases

•Heart failure and cancer share a bidirectional relationship where CVD promotes tumor growth, and tumor progression, in turn, suppresses cardiac remodeling and improves cardiac contractile function.•CVD and cancer share mechanisms such as chronic inflammation, immune modulation, and extracellular matrix remodeling.•Genetic mouse models highlight how tumors affect the host microenvironment resulting in the secretion of factors that induce systemic immune modulation and tissue repair.