Raised glycated albumin levels were associated with a 10.9-fold higher odds of post-MI complications and demonstrated superior diagnostic accuracy compared to HbA1C in diabetic patients.
Case-Control (n=260)
No
Do elevated HbA1C and glycated albumin levels predict post-MI complications in type II diabetic patients presenting with STEMI?
260 type II diabetic patients with ST-elevation myocardial infarction (STEMI) in a tertiary care hospital (Indian population).
Elevated levels of HbA1C and glycated albumin (GA)
Age- and sex-matched controls who did not develop post-MI complications
Post-MI complications (adverse cardiovascular outcomes)composite
Glycated albumin demonstrates superior diagnostic accuracy compared to HbA1C for predicting post-MI complications in type II diabetic patients with STEMI.
Effect estimate: aOR 10.9 (95% CI 8.42-12.22)
Absolute Event Rate: 98.4% vs 42.3%
p-value: p=<0.001
Background: Diabetes mellitus significantly increases the risk of adverse cardiovascular outcomes following ST-elevation myocardial infarction (STEMI). Glycaemic markers like HbA1C and glycated albumin (GA) may serve as prognostic indicators, but their predictive validity in Indian diabetic populations remains underexplored. Thus, this study was conducted to evaluate the prognostic value of HbA1C and GA in predicting adverse cardiovascular outcomes post-MI in diabetic patients. Methods: A matched case-control study was conducted among 260 type II diabetic STEMI patients in a tertiary care hospital. Cases were those developing post-MI complications; age- and sex-matched controls who did not. Glycaemic markers and clinical risk factors were analyzed using conditional logistic regression and ROC analysis. Results: Raised HbA1C and GA levels were significantly associated with higher odds of post-MI complications (aOR: 5.55 and 10.9, respectively). GA showed superior diagnostic accuracy (AUC: 0.948) and specificity (57.6%) over HbA1C. Conclusion: GA is a promising biomarker for risk stratification in diabetic patients post-MI and may complement HbA1C in clinical practice. Keywords: Cardio-vascular Diseases, Diabetes Mellitus, Glycated albumin, HbA1C, Myocardial Infarction
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Atiya A. Inamdar
Humayun Kabir
Bangladesh Council of Scientific and Industrial Research
International Journal of Health Sciences
Institute of Medical Sciences
Medical College and Hospital, Kolkata
Tamil Nadu Government Multi Super Speciality Hospital
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Inamdar et al. (Sun,) conducted a case-control in Type 2 diabetes mellitus with ST-elevation myocardial infarction (STEMI) (n=260). Raised glycated albumin (>14.3%) vs. Normal glycated albumin (≤14.3%) was evaluated on Adverse cardiovascular events post-MI (aOR 10.9, 95% CI 8.42-12.22, p=<0.001). Raised glycated albumin levels were associated with a 10.9-fold higher odds of post-MI complications and demonstrated superior diagnostic accuracy compared to HbA1C in diabetic patients.
synapsesocial.com/papers/6a0ebfff8da6dd046147ad45 — DOI: https://doi.org/10.53730/ijhs.v9n2.15729