Abstract The biomedical domain has witnessed a significant incorporation of nanotechnology in recent years. Zeolitic imidazolate framework‐8 (ZIF‐8) has demonstrated potential as a pH‐responsive smart targeted release nanoplatform for antibacterial and anti‐inflammatory agents, attributed to its superior biocompatibility and robust physicochemical stability. Furthermore, the high porosity and substantial surface area of ZIF‐8 enable significant drug‐loading capacity and the encapsulation of various agents, including small inorganic molecules and large protein molecules. Moreover, ZIF‐8 composite materials exhibit unique pH sensitivity and photosensitivity, resulting in decomposition and subsequent release of antibacterial and anti‐inflammatory agents under acidic conditions and near‐infrared irradiation, respectively. This review aims to synthesize recent advancements in pH‐responsive and photosensitive ZIF‐8 as a dual‐responsive smart targeted release nanoplatform in antibacterial therapy and wound regeneration. Furthermore, this review elucidates the benefits and operational principles of ZIF‐8 as a smart targeted release nanoplatform for antibacterial efficacy and wound healing, with the objective of providing a comprehensive rationale and guidance for investigations into the antibacterial properties and the promotion of wound regeneration facilitated by ZIF‐8.
Su et al. (Thu,) studied this question.