Mucuna pruriens (Mp) is one of the most widely used medicinal plants in Ayurveda, the traditional Indian system of medicine. Recognized for its high nutritional value, Mp has long been an important food source in Asia, the Americas, and various African countries. Additionally, it serves as a cover crop and animal fodder. Traditionally, Mp has been employed as an antivenom for snake bites. Research suggests that it possesses numerous beneficial properties, including anti-oxidative, anti-inflammatory, anti-epileptic, and anti-microbial activities. It is also commonly used as a potent aphrodisiac.Parkinson's disease (PD) is a complex neurological disorder characterized by the gradual degeneration of dopaminergic neurons, leading to movement impairments such as resting tremors, rigidity, and bradykinesia. The anti-Parkinsonian potential of Mp has been investigated since the 19thcentury, with various studies highlighting its neuroprotective effects. Levodopa (L-DOPA), a key phytoconstituent of Mp, is primarily responsible for its anti-PD properties. Besides L-DOPA, other bioactive compounds present in Mp exhibit antioxidant and neuroprotective effects.This review explores the ethnomedicinal applications, phytochemistry, and anti-PD potential of Mp based on available literature, including preclinical studies and select clinical trials involving PD patients. Furthermore, it underscores the significance of Mp in PD management through a comprehensive analysis of existing research. These insights may contribute to the development of future therapeutic strategies for more effective PD treatment.
Kumbar et al. (Wed,) studied this question.