Mechanical Ventilation (MV) is a common intervention in Cardiac Intensive Care Units (CICUs); however, its effect on in-hospital mortality remains controversial. This study aimed to investigate the association between MV and in-hospital mortality among patients in the CICU using data from the eICU Collaborative Research Database. Patients were categorized based on whether they received MV, and propensity score matching was applied to adjust for baseline differences. The primary outcome was in-hospital mortality, which was analyzed using logistic regression and sensitivity analyses. A total of 12,480 patients in the CICU were included, with 4390 receiving MV and 8090 not receiving MV. In-hospital mortality was notably higher among MV patients (16.0 %) than among those who did not receive MV (4.7 %, p < 0.001). After adjusting for confounding factors, MV remained associated with increased mortality, with an odds ratio of 4.16 (95 % CI 3.40‒5.12) in the matched cohort. Sensitivity analyses confirmed these findings, particularly in patients with acute respiratory failure and shock. These results demonstrate that CICU patients receiving MV have a higher mortality risk, underscoring the need for judicious clinical use of MV.
Tian et al. (Wed,) studied this question.
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