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This is a Literature Review study.

September 10, 2025

Development and method validation of RP-HPLC Method- A Review

Key Points

Development of rp-hplc methods presents significant challenges, particularly in column stability and sample preparation.
Recent advancements in hyphenated methods like rp-hplc paired with lc-ms enhance pharmaceutical development processes.
Adopting new techniques can improve optimization in rp-hplc, fostering innovation in drug formulation.
This review calls for continuous advancement in rp-hplc methodologies, highlighting the need for addressing existing obstacles.

Abstract

Abstract: The development of RP HPLC methods is not without difficulties, despite its many advantages. These difficulties include problems with column stability, sample preparation, and optimization. This article describes new techniques that can be used with the RP-HPLC process to design and produce novel pharmaceuticals. Additionally covered are instances of more current developments in hyphenated methods like RP-HPLC. We intend to stimulate ongoing innovation and advancement in the developing field of pharmacy by examining the most recent developments, applications, and difficulties in the creation of RP-HPLC methods. Keywords: RP-HPLC, LC-MS and API (Active Pharmaceutical Ingredient)

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