ABSTRACT Defatted rice bran (DRB), a by‐product of Thai Oryza sativa , is rich in dietary fiber and antioxidant phytochemicals. This study investigated the bioaccessibility, antioxidative efficacy, and prebiotic potential of DRB in colorectal cancer (CRC) models. Simulated gastrointestinal digestion demonstrated high bioaccessibility of flavonoids (79%) and phenolics (62%), along with substantial antioxidant activity: DPPH (57%), FRAP (83%), and ORAC (74%). In vitro, digested DRB significantly reduced intracellular reactive oxygen species (ROS; −33%, p 0.6, FDR < 0.05). These findings indicate that DRB possesses potent antioxidative and prebiotic properties, supporting its use as a safe, multifunctional dietary ingredient for CRC risk reduction.
Wunjuntuk et al. (Tue,) studied this question.