INTRODUCTION: The present study was conducted to evaluate the association between periodontitis and sperm quality. METHODS: A systematic review and meta-analysis of any observational studies published from inception to August 2024 in Scopus, PubMed, ScienceDirect, EBSCO, and Google Scholar was performed. A JBI checklist was used to assess the risk of bias. Statistical analysis was performed using Stata version 17. Fixed- or random-effects model meta-analyses were used and reported as pooled odds ratio (OR) and 95% confidence interval (CI). RESULTS: Six studies involving 987 men aged ≥21 years were included in the systematic review, and four of them were included in the meta-analysis. Periodontitis was significantly associated with any sperm abnormalities (OR = 1.86; 95% CI = 1.32-2.60; p = 0.0003). In subgroup analysis, significant associations were found between periodontitis and sperm quality in Asian populations (OR = 2.13; 95% CI = 1.48-3.07; p = 0.0001) and subnormal sperm count (OR = 2.08; 95% CI = 1.03- 4.23; p = 0.04). When stratified by the severity, moderate-to-severe periodontitis was associated with sperm quality (OR = 2.76; 95% CI = 1.78-4.26; p <0.0001). CONCLUSION: This study shows that periodontitis is associated with any sperm abnormalities.
Ridho et al. (Wed,) studied this question.
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