Abstract P12: Application of Novel Immune Signatures for the Early Detection of Colorectal Cancer

Key Points

• A novel 2-gene signature detected colorectal cancer with 82% sensitivity and 78% specificity in an independent cohort.
• The 2-gene RT-qPCR assay showed impressive sensitivity of 76-88% for early-stage colorectal cancer, outpacing traditional markers.
• Bioinformatics methods, including multivariate binary logistic regression, helped identify and validate the diagnostic potential of the gene signature.
• This approach may fill a clinical gap for reliable screening of early-stage colorectal cancer among patients.