Research Progress on Salicylic Acid Content Detection Technology in Aspirin

Aspirin is a common drug. During storage, the influence of acids, bases, or incomplete acetylation can lead to the production of free salicylic acid. Salicylic acid serves as a key basis for measuring the decomposition rate of aspirin tablets. Salicylic acid can cause discomfort to the human body and lead to diseases. Therefore, detecting the salicylic acid content in aspirin is of vital importance. Currently, the primary methods for detecting salicylic acid include colorimetry, chromatography, and spectrophotometry. This study summarizes and generalizes the main detection methods and research progress of salicylic acid content in aspirin.