Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 demonstrates effective brain penetration and tubulin destabilization to target glioblastoma.
• KEY EVIDENCE: Pharmacokinetic studies in mice reveal favorable absorption and distribution of RGN6024 in the brain.
• APPROACH: The research assesses the molecular properties and effects of RGN6024 on tumor growth in glioblastoma.
• SIGNIFICANCE: This small-molecule treatment may provide a new therapeutic option for patients with glioblastoma, a challenging brain tumor.