Table S11 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 effectively destabilizes tubulin, showing promise for glioblastoma treatment.
• KEY EVIDENCE: Pharmacokinetic analysis indicates significant brain penetration and favorable plasma levels of RGN6024.
• APPROACH: The study conducted animal trials with rats to evaluate pharmacokinetic parameters.
• SIGNIFICANCE: This research highlights a potential new strategy in targeting glioblastoma through brain-penetrant small molecules.