Supplementary figure S1 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

• MAIN FINDING: Decr2 expression modulates the efficacy of immunotherapy by affecting tumor cell resistance.
• KEY EVIDENCE: Tumor cell models with Decr2 knockdown demonstrated resistance to CD8+ T cell killing in vitro.
• APPROACH: The study utilized transplantable tumor cell models and examined the impact of Decr2 expression.
• SIGNIFICANCE: Understanding Decr2's role helps in improving immunotherapy strategies for treating tumors.