With the growing use of stem cells in burn treatment, their notable therapeutic effects, ease of accessibility (e.g., peripheral blood stem cells), and broad availability have significantly elevated their research value. This review explores the role of stem cell-based strategies in advancing drug discovery for wound healing, with emphasis on their underlying mechanisms, therapeutic potential, and translational applications. Wound healing proceeds through haemostasis, inflammation, proliferation, and remodelling-processes mediated by cellular events, cytokines, and key pathways such as NF-κB, PI3K/Akt/mTOR, and Wnt/β-catenin. Stem cells play a pivotal role in this process by promoting angiogenesis, extracellular matrix (ECM) formation, and collagen remodelling, while also modulating inflammation and enhancing tissue regeneration through the secretion of TGF-β and VEGF. Stem cell-based interventions represent a promising avenue for drug development in wound healing, offering solutions to unmet clinical needs through innovative therapies and personalized medicine. This review highlights recent progress and outlines future directions in this rapidly evolving field.
Lu et al. (Thu,) studied this question.
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