Diabetes Mellitus is a prominent contributor to degenerative diseases globally and is often associated with hepatic injury. The dysfunction of the liver is characterized by cirrhosis, inflammation, apoptosis, and impaired antioxidant defense mechanisms. Our goal was to estimate the hepato-protecting properties of Liposomal resveratrol (LR) administered at 20 and 40 mg/kg in diabetic rat models and compare them with those of resveratrol at 40 mg/kg. The diabetes was induced in them using streptozotocin (STZ) (65 mg/kg) during a five-week long dosage. This study investigates the effects of LR and resveratrol on glucose levels, body weight, inflammatory markers (TNF-α, IL-6, NF-κB), oxidative stress parameters (MDA, catalase, GPx), apoptotic markers (caspase-3, BAX, BCL-2), liver function enzymes (SGOT, SGPT, GGT), and histopathological alterations in liver tissue. Diabetic rats infused with STZ exhibit changes in hepatic function markers, and increased inflammatory and apoptotic responses, all of which were reversed by administering LR. This reversal occurred through the downregulation of TNF-α and IL-6, inhibition of NF-κB translocation, upregulation of BCL-2, and downregulation of caspase 3 and Bax protein levels. STZ-induced diabetic rats experience a significant disruption in their antioxidant defense system, whereas LR administration notably inhibits lipid peroxidation and significantly enhances the activity of antioxidant enzymes. The histopathological analysis of liver tissue in STZ rats showed morphological changes when compared to the normal rats. This was indicative of the development of acute inflammations. In contrast, LR treatment resulted in normal liver histology with minimal presence of chronic inflammatory cells, predominantly lymphocytes. Remarkably, resveratrol alone was less effective than LR in restoring these parameters in diabetic subjects. Administration of LR effectively mitigates oxidative stress and hepatic impairment caused due to diabetes, suggesting its potential as a therapeutic agent to reduce liver dysfunction in diabetic patients.
Alanazi et al. (Thu,) studied this question.