Essential thrombocythemia (ET) is a type of myeloproliferative neoplasm with uncontrolled production of megakaryocytes. It is characterized by the presence of large and giant megakaryocytes in the bone marrow, which leads to an increase in platelet count. This condition can cause both thrombosis and bleeding. In children, the clinical presentation of ET can vary. Unlike adults, who often experience hemorrhagic and thrombotic events, most pediatric patients do not have any symptoms. Instead, they may only have changes in their blood count. The diagnostic criteria and risk factors for ET in adults are not directly applicable to children. Similarly, the treatment recommendations for adults with ET cannot be directly applied to children. The genetic profile of ET in children also differs from that in adults, leading to differences in the frequency of specific driver mutations and the number of cases of the disease. The aim of this study is to describe the clinical and laboratory features, course, and treatment of ET in children and adolescents.
Kralichkin et al. (Fri,) studied this question.