What type of study is this?

September 10, 2025

Clinical and Hematological Profiling of Dengue Fever: Impact of Age, Gender, and Comorbidities on Disease Severity

MNMuhammad Zaeem NomanAbdul Wali Khan University Mardan SRSyeda RizviPunjab Medical College ATA. K. A. Abd Talib

Key Points

Dengue hemorrhagic fever patients had severe symptoms like abdominal pain and elevated liver enzymes, indicating critical health risks.
A significant incidence of thrombocytopenia was observed in dengue hemorrhagic fever patients, emphasizing its importance in assessing disease severity.
Higher rates of DHF were linked to comorbidities such as hepatitis C and diabetes, suggesting increased complexity of cases.
Age was a notable factor, with younger DHF patients showing different clinical presentations compared to older dengue fever patients.

Abstract

This study analyzed 280 dengue patients (77.8% male, 22.1% female) with a median age of 30 years. The highest incidence occurred in the 40–60 age group (53%). Dengue fever (DF) was predominant (229 cases), while dengue hemorrhagic fever (DHF) affected 51 patients, with males showing higher infection rates (p=0.03). DHF patients were younger (median age 24.5 vs. 30 years) and exhibited severe symptoms like abdominal pain, rash, and elevated liver enzymes (AST/ALT levels 10x and 2.5x higher, respectively; p<0.05). Thrombocytopenia (<69,000 cells/mm³) was significant in DHF (p=0.001). Common symptoms included myalgia (91%), headache (80%), and vomiting (52.5%). Hemorrhagic manifestations (e.g., epistaxis, melena) occurred in 50% of patients. Comorbidities (e.g., hepatitis C, diabetes) worsened outcomes, increasing DHF risk (32% vs. 20%; p=0.01) and mortality (CFR=2.5%). Serological testing confirmed positivity for NS1 (41.7%), IgG (30%), and IgM (27.8%).

Ask AI

Helpful

Bookmark

View Full Paper