The pharmacological activities of Schiff bases generated from isatin include antibacterial, antifungal, anti-inflammatory, antiviral, anticancer, antioxidant, anticonvulsant, analgesic, anti-tubercular, and anti-depression. Because of these activities, they find numerous applications in various fields, particularly medical and pharmaceutical. Some have the most potent antioxidant activity, protecting cells against free radicals linked to diseases like cancer, heart disease, stroke, inflammation, and aging, making antioxidant activity more significant. As a result, the importance of antioxidants in pharmacology and medicine is expanding. The reagents 2, 2-Diphenyl-1-picrylhydrazyl (DPPH), CUPRAC and 2, 2′-Azino-bis (3-ethyl benzothiazoline-6-sulfonic acid) are used to determine the antioxidant ability of the naturally occurring and synthetic compounds. Standard antioxidants such as Quercetin, Trolox, and L-ascorbic acid compare a compound's antioxidant activity. The current review summarises the antioxidant activity of isatin's Schiff base derivatives and their metal complexes.
Sanguni et al. (Thu,) studied this question.