Comparative Evaluation of Marketed Tablet Formulations by Uv Spectroscopy

This study explores the application of UV-Visible spectrophotometry for the quantitative analysis and quality assessment of pharmaceutical drugs, specifically Paracetamol, Ofloxacin, Aspirin, Amlodipine. UV-Visible spectrophotometry is a widely used analytical technique that measures the absorption of ultraviolet or visible light by chemical substances, based on the principles of the Beer-Lambert law. This method enables the determination of drug concentration and purity by evaluating the relationship between absorbance and concentration at specific wavelengths. In this research, standard and sample solutions of drugs were prepared using appropriate solvents, and their absorbance was measured at their respective maximum wavelengths (λmax). Calibration curves were constructed by plotting absorbance against known concentrations of the standard solutions, establishing linear equations for each drug. These calibration models were then used to estimate the concentration of active pharmaceutical ingredients in commercial tablet formulations. The study also reviewed the pharmaceutical profiles, pharmacokinetics, mechanisms of action, and manufacturing details of both drugs to provide a comprehensive understanding of their analytical and therapeutic significance. The aim of this work is to highlight the reliability, simplicity, and costeffectiveness of UV spectrophotometry as a tool for routine quality control in pharmaceutical analysis, especially in ensuring compliance with pharmacopeial standards