August 5, 2025

Electrochemically Driven Bromochlorination of Alkenes

Key Points

Electrochemically driven bromochlorination creates organic halides from alkenes without active halogen sources.
The method employs paired electrolysis with nBu4NBr and C2Cl6 to generate halogen intermediates.
The process achieves high chemo-, regio-, and diastereoselectivity without additives or catalysts.
This approach provides a more environmentally friendly strategy for creating valuable halogenated compounds.

Abstract

Organic halides play a crucial role in various fields such as pharmaceuticals, pesticides, and materials. The dihalogenation of alkenes is an important pathway to obtain organic halides. However, traditional methods often rely on highly active halogen sources, which may present environmental concerns. In this study, we have developed an efficient electrochemically driven approach for the bromochlorination of alkenes. Traditionally inert nBu4NBr and C2Cl6 were added as the halogen sources to generate Br cation and Cl anion intermediates through paired electrolysis. These intermediates were subsequently captured by the alkenes, thus facilitating the formation of bromochlorides. This strategy successfully avoids the use of highly active halogen sources. Most importantly, the reaction condition is very simple without any additives or catalysts, providing bromochloride products in high chemo-, regio-, and diastereoselectivities

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