Synthesis of 4-(arylthio)isoquinolin-1(2H)-ones via TBHP-mediated sequential amidation/thioetherification of N-alkylisoquinolinium salts

Key Points

• This method demonstrates efficient synthesis of 4-(arylthio)isoquinolin-1(2H)-ones through TBHP-mediated reactions.
• The sequence involves 1,4-difunctionalization yielding high product yields under metal-free conditions.
• A practical approach utilizing TBHP achieves this transformation of N-alkylisoquinolinium salts effectively.
• The findings support a simpler synthetic route, avoiding the need for metal catalysts in producing complex molecular frameworks.