ABSTRACT Objectives Diabetes mellitus (DM) has a strong bidirectional relationship with mental disorders, collectively increasing the risk of mortality. We aim to analyze the mortality trends related to DM and associated mental disorders while exploring demographic and regional disparities in the United States from 1999 to 2023. Methods Death records were obtained from the Centers for Disease Control and Prevention‐Wide‐ranging ONline Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2023. Crude and age‐adjusted mortality rates (AAMRs), measured per 100,000 people, were calculated and standardized to the 2000 US standard population. Annual percent changes (APCs) in AAMRs and crude mortality rates (CMRs) were computed through the Joinpoint regression program and data stratification was done based on sex, race, age, and geographical regions. Results A total of 1,332,198 death records indicated the presence of both DM and mental disorders. AAMR increased fourfold from 1999 (9.5) to 2023 (40.4) per 100,000 population. Notable increase shifts were noted in AAMR across different periods between 1999 and 2021 (APC: 1999–2005: 14.98; 2005–2018: 2.92; 2018–2021: 8.98), after which it declined sharply until 2023 (APC: −6.42). Males (36.8) had elevated AAMRs in comparison to females (22.4). Non‐Hispanic (NH) American Indians contributed to most of the AAMR (39.8). CMR was 11‐fold higher in older adults as compared to those aged between 35 and 64 years. Regionally, AAMRs in nonmetropolitan areas (35.9) and Midwest regions (34.7) were the highest. Conclusions Further research and targeted interventions are needed for in‐depth evaluation of these rising mortality trends to find the root cause and lower the burden of DM and associated mental disorders.
Hassan et al. (Fri,) studied this question.