Objectives: The primary objective of this study was to assess the prevalence of total serum IgE levels in patients with chronic spontaneous urticaria (CSU) attending the hospital, while the secondary goal was to evaluate the relationship between serum total IgE levels, disease severity, and disease duration. CSU is a common allergic skin disorder characterized by the recurrent appearance of itchy hives (wheals), angioedema, or both, occurring daily or at least twice weekly for 6 weeks or more. CSU presents with varying symptoms and has complex underlying causes. While its exact cause remains unclear, the prevailing hypothesis points to autoimmune dysfunction, where autoantibodies target immunoglobulin E (IgE) or its receptors, leading to histamine release from basophils and mast cells. Materials and Methods: This was a cross-sectional study that included 97 patients diagnosed with CSU. Total serum IgE levels and disease severity were assessed. Results: The total serum IgE levels ranged between 32 and 942 IU/mL, with a mean score of 200 IU/mL. The prevalence of elevated IgE levels (>150 IU/mL) was 50.5% among patients. Patients with higher IgE levels tended to have more severe disease and longer disease duration. Significant positive correlations were seen between increased total IgE and chronic urticaria severity and the duration (r = 0.663, P < 0.001), (r = 0.518, P < 0.001), respectively. Conclusion: The total serum IgE levels were frequently elevated in patients with CSU, which were associated with a higher disease severity and duration.
Farouk et al. (Tue,) studied this question.