Abstract Background Transarterial radioembolisation (TARE) is a treatment for liver malignancies, involving the injection of radioactive microspheres in the hepatic artery (HA). Tumour-to-nontumour uptake varies among patients, possibly influenced by patient-specific blood flow profiles. To examine the impact of HA blood flow rate and high microsphere dosages on microsphere distribution in normal liver parenchyma, ex vivo magnetic resonance imaging (MRI)-guided machine perfusion experiments were conducted in porcine livers. Materials and methods Porcine livers were subjected to oxygenated normothermic machine perfusion at three HA flow rates (0.02, 0.15, and 0.22 mL/min/g liver tissue; n = 3 per condition). Five fractions of 250 mg nonradioactive 165 Ho-loaded microspheres were administered to n = 9 livers, and four additional fractions of 1,000 mg to n = 6 livers. Dynamic contrast-enhanced and Ho-sensitive T2*-weighed MR scans were acquired to extract perfusion rates, fictive dose maps, and homogeneity indices (HI). Results Microsphere distribution correlated moderately with perfusion rate at low HA flow rate ( r = 0.611), and very strongly at higher HA flow rates ( r = 0.977 and 0.951 for 0.15 and 0.22 mL/min/g, respectively). Homogeneity increased with increasing flow rates, with HIs ranging from 3.68–4.72 at low, to 2.01–2.66 at medium, and 1.60–2.36 at high HA flow rate. HI decreased with higher microsphere concentrations, though distribution patterns remained unchanged. Conclusion In our ex vivo model, higher HA flow rates resulted in more homogeneous microsphere distributions. The impact on tumourous tissue needs further investigation to determine whether pre-TARE HA blood flow measurements could improve microsphere distribution predictions. Relevance statement Mapping of the hepatic arterial blood flow rate before transarterial radioembolisation and adjusting the treatment accordingly may help to improve outcomes for patients with liver cancer. Key Points Parameters influencing microsphere distribution were studied in MRI-perfused healthy porcine livers. Higher hepatic arterial blood flow rates led to more homogeneous microsphere distributions. Administering large numbers of microspheres did not alter microsphere distribution patterns. Impact on tumour tissue should be further investigated. Graphical Abstract
Snoeijink et al. (Wed,) studied this question.
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