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September 10, 2025Open Access

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults (Adv. Sci. 29/2025)

YZYingjie ZengChengdu University of Traditional Chinese Medicine YCYuening CaoGuilin Medical University SRSenmiao RenChengdu University of Traditional Chinese Medicine

Key Points

The hybrid nano-prodrug effectively delivers dual agents, promoting immunogenic cell death in hepatocellular carcinoma.
Results show significant oxidative stress induction, enhancing therapeutic outcomes compared to standard treatments.
Analysis utilized tumor microenvironment-responsive methods, emphasizing spatiotemporal drug delivery mechanisms.
These findings suggest potential for more effective and multidimensional therapy for liver cancer patients.

Abstract

Advanced ScienceVolume 12, Issue 29 71032 FrontispieceOpen Access Responsive ROS-Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults (Adv. Sci. 29/2025) Yingjie Zeng, Yingjie ZengSearch for more papers by this authorYuening Cao, Yuening CaoSearch for more papers by this authorSenmiao Ren, Senmiao RenSearch for more papers by this authorChaozheng Zhang, Chaozheng ZhangSearch for more papers by this authorJianan Liu, Jianan LiuSearch for more papers by this authorKe Liu, Ke LiuSearch for more papers by this authorYan Wang, Yan WangSearch for more papers by this authorHongyu Chen, Hongyu ChenSearch for more papers by this authorFengjiao Zhou, Fengjiao ZhouSearch for more papers by this authorXiuli Yang, Xiuli YangSearch for more papers by this authorXian Ge, Xian GeSearch for more papers by this authorTingting Zhang, Tingting ZhangSearch for more papers by this authorTianbao Wang, Tianbao WangSearch for more papers by this authorYao He, Yao HeSearch for more papers by this authorDefang Li, Defang LiSearch for more papers by this authorChuantao Zhang, Chuantao ZhangSearch for more papers by this authorJun Lu, Jun LuSearch for more papers by this author Yingjie Zeng, Yingjie ZengSearch for more papers by this authorYuening Cao, Yuening CaoSearch for more papers by this authorSenmiao Ren, Senmiao RenSearch for more papers by this authorChaozheng Zhang, Chaozheng ZhangSearch for more papers by this authorJianan Liu, Jianan LiuSearch for more papers by this authorKe Liu, Ke LiuSearch for more papers by this authorYan Wang, Yan WangSearch for more papers by this authorHongyu Chen, Hongyu ChenSearch for more papers by this authorFengjiao Zhou, Fengjiao ZhouSearch for more papers by this authorXiuli Yang, Xiuli YangSearch for more papers by this authorXian Ge, Xian GeSearch for more papers by this authorTingting Zhang, Tingting ZhangSearch for more papers by this authorTianbao Wang, Tianbao WangSearch for more papers by this authorYao He, Yao HeSearch for more papers by this authorDefang Li, Defang LiSearch for more papers by this authorChuantao Zhang, Chuantao ZhangSearch for more papers by this authorJun Lu, Jun LuSearch for more papers by this author First published: 07 August 2025 https://doi.org/10.1002/advs.71032AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechatBluesky Graphical Abstract A Cascade Strategy for Hepatocellular Carcinoma In article number 2501420, Yingjie Zeng, Jun Lu, and co-workers present a tumor microenvironment-responsive hybrid nano-prodrug (CA-4S2@ES-Cu) that achieves spatiotemporal co-delivery of CA-4 (angiogenesis inhibitor) and ES-Cu (mitochondrial cuproptosis inducer). Synergistic GSH depletion amplifies oxidative stress and DAMPs release, activating immunogenic cell death to transcend monotherapy limitations, thereby establishing a multidimensional therapeutic paradigm for hepatocellular carcinoma. Volume12, Issue29August 7, 202571032 RelatedInformation

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