What type of study is this?

September 10, 2025

A reddish nodule developed in a nevus

Key Points

The nodule in the nevus may indicate a potential lymphoproliferative disorder, necessitating further evaluation.
Histological examination revealed characteristics consistent with T-cell abnormalities often seen in skin conditions.
Analysis of clinical presentation and histopathological findings was employed to assess the changes in the nevus.
Identifying similar cases could improve early diagnosis and treatment of dermatological conditions related to nevi.

Abstract

JDDG: Journal der Deutschen Dermatologischen GesellschaftEarly View CASE STUDY A reddish nodule developed in a nevus Christos Topalidis, Christos Topalidis Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, GreeceSearch for more papers by this authorMattheos Bobos, Mattheos Bobos Department. of Biomedical Sciences, School of Health Sciences, International Hellenic University, Alexandrian Campus, Sindos, Thessaloniki, GreeceSearch for more papers by this authorLeonidas Pavlidis, Leonidas Pavlidis Department of Plastic Surgery, School of Medicine, Aristotle University of Thessaloniki, GreeceSearch for more papers by this authorFotini Vrani, Fotini Vrani First Dermatology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GreeceSearch for more papers by this authorAndreas Moutsoudis, Andreas Moutsoudis First Dermatology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GreeceSearch for more papers by this authorTriantafyllia Koletsa, Corresponding Author Triantafyllia Koletsa email protected orcid.org/0000-0002-4435-3532 Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, Greece Correspondence Triantafyllia Koletsa, MD, PhD, Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece. Email: email protectedSearch for more papers by this author Christos Topalidis, Christos Topalidis Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, GreeceSearch for more papers by this authorMattheos Bobos, Mattheos Bobos Department. of Biomedical Sciences, School of Health Sciences, International Hellenic University, Alexandrian Campus, Sindos, Thessaloniki, GreeceSearch for more papers by this authorLeonidas Pavlidis, Leonidas Pavlidis Department of Plastic Surgery, School of Medicine, Aristotle University of Thessaloniki, GreeceSearch for more papers by this authorFotini Vrani, Fotini Vrani First Dermatology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GreeceSearch for more papers by this authorAndreas Moutsoudis, Andreas Moutsoudis First Dermatology Department, Medical School, Aristotle University of Thessaloniki, Thessaloniki, GreeceSearch for more papers by this authorTriantafyllia Koletsa, Corresponding Author Triantafyllia Koletsa email protected orcid.org/0000-0002-4435-3532 Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, Greece Correspondence Triantafyllia Koletsa, MD, PhD, Department of Pathology, School of Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece. Email: email protectedSearch for more papers by this author First published: 07 August 2025 https://doi.org/10.1111/ddg.15836Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechatBluesky REFERENCES 1James E, Sokhn JG, Gibson JF, et al. CD4+ primary cutaneous small/medium-sized pleomorphic T-cell lymphoma: a retrospective case series and review of literature. Leuk Lymphoma. 2015; 56(4): 951-957. 10.3109/10428194.2014.938331 CAS PubMed Web of Science® Google Scholar 2Willemze R, Cerroni L, Kempf W, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019; 133(16): 1703-1714. 10.1182/blood-2018-11-881268 CAS PubMed Web of Science® Google Scholar 3Alaggio R, Amador C, Anagnostopoulos I, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid neoplasms. Leukemia. 2022; 36(7): 1720-1748. 10.1038/s41375-022-01620-2 PubMed Web of Science® Google Scholar 4Vergier B, Jansen PM, Mitteldorf C, et al. Primary cutaneous CD4-positive small or medium T-Cell lymphoproliferative disorder. In: F Ahmed, IA Cree, D Jong, et al. (Eds): WHO Classification of Tumours: Haematolympoid Tumours Part B. 5th edition. Lyon: International Agency for Research on Cancer (IARC), 2024: 682-684. Google Scholar 5Beltzung F, Ortonne N, Pelletier L, et al. Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorders: A clinical, pathologic, and molecular study of 60 cases presenting with a single lesion: A multicenter study of the French Cutaneous Lymphoma Study Group. Am J Surg Pathol. 2020; 44(7): 862-872. 10.1097/PAS.0000000000001470 PubMed Web of Science® Google Scholar 6Xu X, Chu E. " Halo nevus". In: DE Elder, D Massi, RA Scolyer, et al. (Eds): WHO Classification of Skin Tumours. 4th edition. Lyon: International Agency for Research on Cancer (IARC), 2018: 91-92. Google Scholar 7Dadban A, Truchetet F. Cutaneous lymphoid hyperplasia on a preexistent melanocytic nevus. Dermatology. 2008; 217(3): 199-200. 10.1159/000141650 CAS PubMed Web of Science® Google Scholar 8McNiff JM, Glusac EJ. Histologic features of melanocytic nevi seen in association with mycosis fungoides. J Cutan Pathol. 2003; 30(10): 606-610. 10.1034/j.1600-0560.2003.00127.x PubMed Web of Science® Google Scholar 9Davick JJ, Gaughan E, Barry M, Gru AA. Primary cutaneous small/medium CD4+ T-cell lymphoproliferative disorder occurring in a patient with metastatic melanoma. Am J Dermatopathol. 2018; 40(1): 60-63. 10.1097/DAD.0000000000000960 PubMed Web of Science® Google Scholar 10De la Torre-Gomar FJ, Llamas-Molina JM, Pegalajar-García MD, et al. Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder following COVID-19 vaccination-what do we know about lymphoproliferative disorders and cutaneous lymphomas after COVID-19 vaccination? A report of an atypical case and a review of the literature. Life (Basel). 2024; 14(3): 386. CAS PubMed Google Scholar Industry InsightsBeyond the Skin Barrier – The Role of Type 2 Inflammation in Atopic Dermatitis Across the AgesExploring new worlds: biology of the IL-23 pathway beyond the skin Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation Industry InsightsHaarsprechstunde" – Input für die PraxisFortgeschrittenes malignes MelanomYuri Sankawa, Lokale Akne-Therapie im Gesicht und am RumpfMittelschwere bis schwere atopische DermatitisDr. Marion Hofmann-Assmus, Fürstenfeldbruck, Highlights of 2024 EADV CongressDr. April Armstrong, Dr. William Tillett, Dr. Tiago Torres, Dr. med. Matilde Iorizzo, Dr. Maria-Angeliki Gkini, About scars, scarring and treatment optionsSkinAlliance Forum 2024 : Dernières avancées en matière d'innovation pour une dermatologie plus diversifiée et plus inclusiveA Series of Debates to Take Psoriasis Management Forward

Ask AI

Mark Helpful

Bookmark

Relay