This study evaluated functional and inflammatory outcomes after pars plana vitrectomy (PPV) in patients with persistent vitreous opacities due to infectious and noninfectious uveitis unresponsive to medical therapy. Twenty-three eyes with noninfectious uveitis and 16 eyes with infectious uveitis were enrolled. Functional and inflammatory parameters were assessed, focusing on best-corrected visual acuity (BCVA), vitreous haze, and inflammation. At 6 months, both vitreous haze and anterior chamber inflammation decreased from severe to minimal levels. BCVA improved in 28 eyes (71.8%), remained stable in five eyes (12.8%), and worsened in six eyes (15.4%). Linear regression analysis showed that preoperative BCVA significantly predicted visual improvement (coefficient = 0.60, 95% confidence interval CI: 0.22-0.98, P = 0.003), while etiology (P = 0.217) and lens status (P = 0.201) were not significant factors (R2 = 0.34). Elevated intraocular pressure occurred in five patients, with two requiring trabeculectomy after 3 months. In two cases, epiretinal membrane formation progressed to tractional retinal detachment within 6 months. PPV is an effective treatment for persistent vitreous opacities, resulting in visual improvement and stabilization of inflammation. Postoperative follow-up is necessary due to potential complications and recurrence.
Alisi et al. (Mon,) studied this question.
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