Effects of Several Polyphenols on Some Hematological and Weight Parameters in Rats with Experimental Hypothyroidism

Deficiency of thyroid hormones in the blood is described as hypothyroidism. Long-term usage of drugs for the treatment of hypothyroidism can lead to serious adverse effects, for example, tachycardia, nervousness, anxiety, tremors, excessive sweating and symptoms can often recur when medication is stopped. For this reason, it is important to find new harmless, natural compounds in the treatment of hypothyroidism. This study was carried out to study the time a rat can find its way in a special labyrinth in thyroid hypothyroidism, the number of erythrocytes, leukocytes in blood, the rate of agglutination of erythrocytes and the total weight of the rat and the weight of the thyroid gland, thymus, spleen, adrenal gland, and studying the effects on it of the sum of polyphenols which separated 9 plants. Adult male rats were housed in standard cages, and hypothyroidism was induced by intragastric administration of mercazolil at a dose of 1.2 mg/100 gr of body weight for 21 days. On day 22 of the experiment, physiological indicators of both the healthy control and hypothyroid groups were assessed. Starting from that day, plant polyphenols were administered to the hypothyroid group with a special intragastric probe at a dose of 10 mg/kg/day for 7 days (6 rats per group, 9 groups in total). In summary, plant polyphenols included geranium sanguineum, vitis vinifera, atraphaxis pyrifolia, pistacia vera, rhus glabra plant polyphenols with a corrective effect on more parameters among the 9 polyphenols. Further research is also currently underway to confirm this information. HIGHLIGHTSPolyphenols are rarely used to treat thyroid dysfunctions. Thyroid diseases, especially hypothyroidism can cause various pathological conditions in the body, including obesity. According to our results, several polyphenols have a corrective effect on certain parameters in the blood and weight indicators in hypothyroidism of the thyroid gland. We found that among the polyphenols used, a dose of 10 mg/kg had a corrective effect on the number of erythrocytes in the blood and on weight indicators. GRAPHICAL ABSTRACT